Plesk will be the control panel for V12 Business Hosting whereby its the only web hosting control panel you'll ever need to build, secure and run websites and applications in the Cloud!
The main difference between Plesk and cPanel lies in their user interface and web servers they support.
Plesk user interface is similar to the WordPress admin panel and supports both Linux & Windows servers.
cPanel has a graphical interface and is compatible with only Linux web servers.